How It Works: Mucosal integrity testing (MIT) measures the impedance of esophageal mucosa, which reflects the tissue’s resistance to electrical current. Healthy mucosal tissue exhibits high impedance, indicating a robust barrier. In contrast, compromised tissue shows lower impedance, indicative of dilated intercellular spaces (DIS), which affects paracellular permeability of the esophageal lumen and can be seen histologically in GERD and EoE. (See Fig. 1).
The MI test is conducted with MiVu™ Endo Cap and performed during routine upper endoscopy by attaching a cap with sensors to the distal end of the endoscope, which is connected to the computer-aided analysis system and software. This test provides real-time impedance measurements and can instantly provide a probability of GERD, non-GERD, and EoE. MiVu adds about two minutes to a typical upper endoscopy. (See Fig. 2).
